Natural Gainz Magazine 18 Reasons Not To Use The Drug Clenbuterol

18 REASONS NOT TO USE THE DRUG CLENBUTEROL

18 REASONS NOT TO USE THE DRUG CLENBUTEROL [PART ONE]

By Jackie Paisley, former IFBB Pro Bodybuilder

18 REASONS NOT TO USE THE DRUG CLENBUTEROL
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I am an “old-timer.” I stopped competing back in the 1990s. My fellow competitors in the Pro ranks mostly thought of clenbuterol as a disappointing, and yucky drug. Some of us ended up gaining fat in lower abs, etc-and losing fat volume in our faces, so we deemed the drug not worth taking.

Evidently, what we found years ago wasn’t in the “memo” or agreed upon by athletes and coaches, today. One thing about “clen” is that it can deliver results at the time they are needed. So this makes it an appealing drug of choice for competitors today. I am writing this article so you can take perhaps a different look at whether this drug is worth trying or not!

18 REASONS NOT TO USE THE DRUG CLENBUTEROL
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I remember the first time I tried clenbuterol (clen). A chemist/famous (or infamous) bodybuilding coach/”steroid guru” made a cherry flavored liquid form and gave it to me.  Since he used his own body as a human petri dish (and as a result is no longer alive) he was fascinated by my metabolism, natural ability to be and stay lean and had his own reasons for using me as an experiment.

“LIKE MANY DRUGS THAT SHOW RESULTS IN OTHER AREAS IT HAS THE UNEXPECTED BENEFIT OF THERMOGENESIS-THAT IS-INCREASING FAT LOSS THROUGH HEAT AND BROWN FAT ACTIVITY (BROWN FAT USES HEAT).”

I didn’t need clen to lose fat but he knew I would show signs of it working fairly quickly. He was thrilled when I started to sweat profusely, in between my shoulder blades, and on my chest (where brown fat is). I really never liked the drug very much. I felt like I couldn’t workout as intensely while taking it, and had other side effects, even at lower doses. I also tried it one other time, and felt the same. So there it is…my short story of clen use, which turned into the long story of long-term damage! It is never too late, they say, so I when I was capable I fixed the damage from clen. How about not causing the damage in the first place? Anybody with me?

Clenbuterol is an asthma drug. This drug works on the system by stimulating receptors in the lungs, called beta cells. Like many drugs that show results in other areas it has the unexpected benefit of thermogenesis-that is-increasing fat loss through heat and brown fat activity (brown fat uses heat). There have been other benefits seen, as well.

Since there is a lot of available information, about what it is-and how it works-I will leave this research up to you. I have done plenty or research myself but have actually FIXED clenbuterol long-term damage in myself and with others-none of whom attributed any or their issues to this drug. So, even though I am leaving the research up to you, you are certainly welcome to read what  I have discovered about this drug.

Every single issue that will be listed here I have researched, addressed, and fixed with people. Not every person has all of the issues. Women tend to have more issues than men and it relates to hCG, LH, and FSH alterations due to clen. Clenbuterol isn’t much different from another asthma drug of the same class or not as far as long-term damage. So, in essence, asthmatics can have this same, or some damage from similar medicine. My son did have some damage, and he was in a very high amount of a similar medicine in the hospital, years, ago. The issue to note here is that asthmatics don’t use as MUCH of this type of medicine as athletes use.

Damage from clen comes from repeated use, sometimes taking 4-5 weeks of use. Combining clen with steroids, with aspartame, anti-estrogens, or sleep supplements with GHB analogues can cause further damage. Many  competitors end up not looking as full at shows, or have a harder time losing fat, and don’t attribute this to the use of clenbuterol. So if you want to just “try it” remember this… it is the “gift” that keeps on taking!

18 REASONS NOT TO USE THE DRUG CLENBUTEROL
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Another clarification that needs to be made is that I am not arguing about whether clen works or not or saying that coaches haven’t found a better way to use it. Many coaches have the focus of how to use clen without its decreasing effects during use. My focus with the body and health is this… Don’t jeopardize your future gains, heath, or metabolism on decisions you make today.

I didn’t always base my decisions on this principle. Now I do. I also didn’t know how to approach writing this article. Each point can be an entire article in itself. So, I decided to make it the “18 reasons why not to use clenbuterol.” I can always come back and write an article about each point.

Watch getting feedback on this article, or advice from someone who is still on anabolics or hasn’t been off of them for years. They may not have a true gauge to realize the effects of some drugs like clen. There may be naysayers who say I don’t have the references or science behind what I am going to say, but I assure you, I do. And even if I made a list of the hundreds of articles I have used, as well as the protocols I have designed to fix these issues, you would still be left needing someone to interpret and fill in the banks. Here are the 18 (bonus 19) reasons not to use OR TRY clenbuterol!

[Most all of these effects do NOT go away once clenbuterol is stopped. They remain and this is dangerous and if other drugs or harmful supplements are tried at a later time the additive effects on the body can be even more harmful! You don’t walk away from this drug unscathed.

It is an insidious, progressive decline in metabolic functions that shows up over time, sometimes as soon as the next contest. I have treated some people YEARS after thy stopped using clen and had issues myself, which fortunately could be fixed, after not using for over 20 years!]

ONE – Clen affects the phrenic nerve (along neck and chest) and the beta 2 receptor continuous stimulation causes changes to beta 2 cell receptivity. This bleeds into functions associated with and influenced by the phrenic nerve. A system called the “complement system” is compromised. This system is responsible for immune functions, including nerve immune health and regeneration, as well as it affects the muscles/neuromuscular junction.

TWO – Matrix metalloproteinses – these special enzymes work within the complement system. Two such proteinases we will address are thermolysin, and meltrin. These enzymes often cannot function normally after clen.

“…ZINC DEFICIENCY AS WELL AS OTHER ISSUES LIKE FLUID BUILD-UP IN THE LUNGS.”

THREE – Zinc deficiency not repaired by simply taking extra zinc. These matrix metalloproteinases need calcium to work and, after clen use, need 4 times as much zinc to function normally. This not only depletes zinc but the body systems which require zinc to function well. I have seen issues with the stomach (like not being able to handle MCT oil), which can be longterm zinc deficiency. Fixing this issue requires specific doses, individualized, and in a sequence, but it can be fixed.

FOUR – Zinc deficiency – copper build-up can occur in the chest (lymphatics) from steroids and anti-estrogens. Anti-estrogens ironically cause estrogen buildup in this area. This combo causes buildup of estrogens in the chest-and clenbuterol allow this mess into the lungs! This causes zinc deficiency as well as other issues like fluid build-up in the lungs.

18 REASONS NOT TO USE THE DRUG CLENBUTEROL
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FIVE – Zinc deficiency number 3! There is a step in the krebs energy cycle involving oxaloacetic acid. The use of clen, plus anabolics, can block something needed for oxaloacetic acid formation called “pyruvate carboxylase.” Without this enzyme, the body will use a substitute called “formic acid.” This process uses up zinc, as well as contributes to stomach lining issues. Some people are so depleted that their oxaloacetic acid step just doesn’t work. In this case-zinc isn’t depleted but they have sub-par krebs cycle activity. (the asthma medicine “intal” causes severe down-regulation of the oxaloacetic acid step of krebs and often shuts it down until fixed).

SIX – Cheyne Stokes respirations. This is fluid build-up in the lungs, usually seen with congestive heart problems. This is an unstable feedback loop in the respiratory control system, stemming from down-regulation of beta 2 cells in lungs (from Clenbuterol), which increases the CO2 and acidity in the lungs, and fluid buildup in the heart/thorax (can be misdiagnosed as a “heart condition”) from estrogen load (arimidex, anabolics) and copper overload (interfering with respiratory rhythm). I have actually seen a case of sleep apnea from this very phenomenon.

“IS THIS PERHAPS ONE CAUSE OF HEART ISSUES LATER IN LIFE?”

SEVEN – Heart muscle. The combination of steroids and clen can cause enlarged actin and myosin smooth muscle fibers. Is this perhaps one cause of heart issues later in life?

EIGHT – Mitochondrial function – with steroids and clen. Steroids alter the way steroids in the liver are detoxed (whether oral or injected). This alone can “steal’ PGC-1 alpha which is directly responsible for mitochondrial function! When PGC-1 alpha is not available the body will try to use a similar protein from the PPAR family. However, clen has altered PPAR availability so mitochondrial function can deteriorate over the years to come.

NINE – Fat storage and distribution issues. Brown fat is located in the chest/neck, and between shoulder blades. It is called brown fat because of capillaries and iron levels and is known for its “wasting” or heat and therefore, energy. Since it creates “heat” it also can affect some white fat stores close to the brown fat areas more than others. This has resulted in the “gaunt” look in the face, especially when getting lean for competition. This often doesn’t not resolve unless significant fat is gained.

TEN – Brown fat mitochondria don’t operate the same as “white fat”so what stimulates brown fat, can INCREASE white fat storage. This effect is not often seen until off clen, and even steroids but after awhile it shows up even while on them. Brown fat mitochondria also rely on a system called the glycerol-3 phosphate “shuttle.” Clen use affects and shuts down this shuttle process which affects mitochondrial function and muscle cell volume (see #14 muscle dehydration).

ELEVEN – Fat storage due to complement system. More adipokines like leptin can be released from adipose (fat) cells. This is connected to increased adipogenesis (fat storage). Since fats cells can operate as endocrine bodies in/and of themselves (for certain functions) they also can react to modulate mast cell activity. This comes from down-regulation of these systems by forcing them down while on the drug. If you want to know what problems a drug will cause later in life just look at what it treats!

“…UNDER CIRCUMSTANCES WHERE THE BODY FEELS THREATENED-YOUR BODY WILL USE NE FOR CALORIES AND YOU COULD DIET UNTIL THE COWS COME HOME AND NOT LOSE FAT.”

TWELVE – Fat storage due to norepinephrine (NE) malfunction. NE is directly involved with fat metabolism. Many fat burning supplements target this system (which they also down-regulate over time). Clen is considered “adrenergic” which means it stimulates adrenaline-related functions. Chronic stimulation to this system (post-ganglionic sympathetic) doesn’t just deplete the adrenals, it actually influences an organ near the heart called the “organ of zuckerlandl (Z).” “Z” is a powerhouse of catecholamines, which include dopamine, NE, and epinephrine. This is an involved, intricate system which communicates with adrenals. NE, which is associated with fat burning, can turn around and become a source of calories!

18 REASONS NOT TO USE THE DRUG CLENBUTEROL
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What this means is that under circumstances where the body feels threatened-your body will use NE for calories and you could diet until the cows come home and NOT LOSE FAT. I have seen it, fixed it and had cases where NE was supplying 18% of daily calories (which is 450 cals out of a 2500 calorie diet), and 25% of calories (625 calories). This effect sometimes isn’t seen while still on anabolics but over time the system is so down-regulated that it can show up. (long-term use of the drug adderal can also cause this).

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THIRTEEN – Beta 2 cells and acidic lungs! Yes, the same principle applies. If you want to rely on asthma drugs, take an asthma drug! There are of course exceptions, but most people do not realize that the condition of asthma is an attempt to heal something in the lungs. Meds like clen interfere with this mechanism. Of course, what do you do if you cannot breathe?

There is a way to use meds and get to the root of the asthma issues, simultaneously. Here is how clen contributes to acidification of the lungs. Asthma is a condition where there is inadequate bacteria in the bronchioles (Chlamydia type). Of course there are other issues as well-and may not be the same with each person. But the main point is that asthma is, initially, an attempt to resolve this bacteria issue. The chronic use of meds just enables the disease to perpetuate and never really resolve.

Some cases show resolution, but the affects from the asthma meds may remain. So, even with someone who doesn’t have asthma, taking courses of clen can also interfere with this bacteria in some way. One way that the bacteria can survive is by using SUGAR. This acidifies the lungs. I have had people feel this and while this is truly being fixed, the person feels like they can’t breathe for a few days! (this often takes use of organic herbs to fix). Another factor may be the extremely low levels of interleukin 12 that I see in former clen users which can contribute to the perpetuation  of this condition. (there is much more to the condition of asthma but taking clen and not clinically “needing it” can cause the above issues).

FOURTEEN – Muscles become dehydrated, and lack full capacity for glycogen storage! Muscle cells are usually 70% water/volume. Through systems which affect those matrix metalloproteinases I mentioned earlier, plus hindrance to cell function called the sodium ATP pump, he neuromuscular junction doesn’t work  as well, and I have seen cases of muscle bellies being 50% water, not 70% and also see people showing up at shows not being able to fill the muscle to capacity with glycogen!

This is related to a function called the Glycerol 3 phosphate shuttle (mentioned above in #10), and ENO3 which is an enzyme involved in glycogen storage. This is a dehydrated muscle and often I see this in competitors, especially ones who have 2  shows rather close together and the clen has already down-regulated. Some of this affect is using certain antihistamines or agents so clen doesn’t down-regulate. This is REALLY STUPID as this further depletes acetylcholine, which muscle needs! PART 2 NEXT MONTH! GAINZMAG


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JACKIE PAISLEY | CONTRIBUTING WRITER

Jakie is a former IFBB Pro Bodybuilder who loved to create posing routines with dance as well as teach the physiology of exercise and diet. She graduated from ASU in exercise physiology, with a minor in music performance. Along her journey to overcome illness from genetic causes and compounding/multiple misdiagnosis she studied, unearthed and discovered amazing secrets that the body holds for healing and growth. In order to access these secrets, she had to fix damage from medicines, doctors, treatments, vaccines, and anabolic steroid use from the past. She is a single mom, and also helps children and adults with health issues that are “hard to crack.”


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